Antidepressants and Side Effects


Does genotyping P450 enzymes predict side effects in patients with depression started on nortriptyline or escitalopram?

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In a study of over 800 patients, P450 genotypes did not explain differences between patients in side effects with nortriptyline or escitalopram. Furthermore, serum drug concentrations appear to only explain variability in the occurrence of a minority of specific side effects.

Hodgson, Karen, et al. “Exploring the role of drug-metabolising enzymes in antidepressant side effects.” Psychopharmacology 232.14 (2015): 2609-2617.