Breast Cancer Guidelines

Beth N. PeshkinTidbits

What is the risk threshold for recommending breast cancer screening with MRI in women who have NOT tested positive for a breast cancer susceptibility gene mutation?

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Most women at high risk for breast cancer (BC) have a positive family history but do NOT have a positive gene test. Women may be candidates for breast MRI screening if they have a lifetime BC risk of >20% due to a personal history of high risk conditions (e.g., lobular cancer in situ, atypical ductal/lobular hyperplasia) or a family history of BC. Many validated models are available for BC risk assessment.

NCCN Clinical Practice Guidelines in Oncology. Breast Cancer Screening and Diagnosis. Version 1.2015. 

NCI. Genetics of Breast & Gynecologic Cancers. Breast cancer risk assessment models.