What is the risk threshold for recommending breast cancer screening with MRI in women who have NOT tested positive for a breast cancer susceptibility gene mutation?[Scroll to bottom for answer]
Most women at high risk for breast cancer (BC) have a positive family history but do NOT have a positive gene test. Women may be candidates for breast MRI screening if they have a lifetime BC risk of >20% due to a personal history of high risk conditions (e.g., lobular cancer in situ, atypical ductal/lobular hyperplasia) or a family history of BC. Many validated models are available for BC risk assessment.