SNP-SNP Interactions In Common Diseases


Do SNP-SNP interactions place a role in the etiology of allergic rhinitis, asthma, & cardiac disease?
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If SNP-SNP interactions play a role in the etiology of the studied conditions, they likely have weak effect sizes, involve lower-frequency variants, and/or involve complex models of interaction that are not captured well by the methods that were utilized.

Murk, William, and Andrew T. DeWan. “Exhaustive Genome-Wide Search for SNP-SNP Interactions Across Ten Human Diseases.” G3: Genes| Genomes| Genetics (2016): g3-116.