Codeine Metabolism in Children with Sickle Cell


What percent of children with sickle cell disease are codeine ultra-rapid or possible ultra-rapid metabolizers?

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In a study conducted at St Jude’s Research hospital, 7.1% of children with sickle cell tested were ultra-rapid or possible ultra-rapid metabolizers … roughly one in 14.

Gammal et al.  Pharmacogenetics for Safe Codeine Use in Sickle Cell Disease