Can low penetrant SNPs identify subsets of the population at an elevated risk of breast cancer?[scroll to bottom for answer]
Yes. A recent study showed that the use of age and polygenic risk score was more effective in sorting women into risk categories than previous sorting by age alone.
Maas P, Barrdahl M, Joshi AD, et al. Breast cancer risk from modifiable and nonmodifiable risk factors among white women in the United States [published online May 26, 2016]. JAMA Oncol