Should NGS or WES be used as a diagnostic tool for CVM?[scroll to bottom for answer]
Yes. After the first patient has been diagnosed with CVM (cardiovascular malformations), the family may be tested more cost efficiently for CVM by pinpointing the genes that would be diagnostic. The genetic testing can be done either by NGS (next generation sequencing) or WES (whole exome sequencing) depending on the diagnostic gene and the discretion of the physician.
Landis, Benjamin J., and Stephanie M. Ware. “The Current Landscape of Genetic Testing in Cardiovascular Malformations: Opportunities and Challenges.” Front. Cardiovasc. Med. Frontiers in Cardiovascular Medicine 3 (2016): n. pag. Web.